Tissue engineering of blood vessel
نویسندگان
چکیده
منابع مشابه
Tissue engineering of blood vessel
Vascular grafts are in large demand for coronary and peripheral bypass surgeries. Although synthetic grafts have been developed, replacement of vessels with purely synthetic polymeric conduits often leads to the failure of such graft, especially in the grafts less than 6 mm in diameter or in the areas of low blood flow, mainly due to the early formation of thrombosis. Moreover, the commonly use...
متن کاملBlood vessel replacement: 50 years of development and tissue engineering paradigms in vascular surgery.
The gold standard material in bypass surgery of blood vessels remains the patient's own artery or vein. However, this material may be unavailable, or may suffer vein graft disease. Currently available vascular prostheses, namely polyethylene terephthalate (PET, Dacron) and expanded polytetrafluoroethylene (ePTFE), perform well as large-caliber replacements, but their long-term patency is discou...
متن کاملNovel biphasic elastomeric scaffold for small-diameter blood vessel tissue engineering.
Compliance mismatch, thrombosis, and long culture times in vitro remain important challenges to the clinical implementation of a tissue-engineered small-diameter blood vessel (SDBV). To address these issues, we are developing an implantable elastomeric and biodegradable biphasic tubular scaffold. The scaffold design uses connected nonporous and porous phases as a basis to mimic, respectively, t...
متن کاملA biphasic elastomeric scaffold for tissue engineering a small-diameter blood vessel
Introduction Scaffolds used for tissue engineering should mimic the native structure of target tissues, gradually degrade with tissue formation, and coexist in a mechanically dynamic environment (sustain and recover from various deformations without mechanical irritations to the surrounding tissues[1, 2]). In the anatomy of a native blood vessel, endothelial cells are separated from surrounding...
متن کاملTissue Engineering for Blood Vessels
The artificial vascular grafts currently in clinical use still have problems with respect to late calcification, restenosis, antithrombotic property, durability, biocompatibility, and safety, and no ideal artificial vascular graft has been developed to date. In view of this, we have been continuing basic experimental studies and their clinical applications in an attempt to develop tissue-engine...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Cellular and Molecular Medicine
سال: 2007
ISSN: 1582-1838,1582-4934
DOI: 10.1111/j.1582-4934.2007.00099.x